A Challenge to the Synthetic Organic Chemist Community – Meet Quindolinocryptotackieine

18 Oct

Attention synthetic organic chemists. Most scientists have skeletons in the closet. Problems they cannot solve and observations they cannot explain. A couple of years ago I was involved in a project to slve the structure of a compound. It had remained unresolved by manual interrogation of the NMR data for over a decade. The application of a computer-assisted structure elucidation system helped resolve the structure. It is described in detail in this publication.

Quindolinocryptotackieine: the elucidation of a novel indoloquinoline alkaloid structure through the use of computer-assisted structure elucidation and 2D NMR

Now, we THINK we have it elucidated correctly. However, we would like to confirm it. Synthesis of the molecule in question, further NMR data generation and a crystal structure would help finish this work fully. This is a call to organic chemists to participate in a hobby project. Anybody want to help? We guarantee a publication etc. The structure is shown below. Contact me at antonyDOTwilliamsATChemspiderDOTcom. Thanks!


About tony

Founder of ChemZoo Inc., the host of ChemSpider ( ChemSpider is an open access online database of chemical structures and property transaction based services to enable chemists around the world to data mine chemistry databases. The Royal Society of Chemistry acquired ChemSpider in May 2009. Presently working as a consortium member of the OpenPHACTS IMI project ( This focuses on how drug discovery can utilize semantic technologies to improve decision making and brings together 22 European team members to develop an infrastructure to link together public and private data for the drug discovery community. I am also involved with the PharmaSea FP7 project ( trying to identify new classes of marine natural products with potential pharmacological activity. I am also one of the hosts for three wikis for Science: ScientistsDB, SciMobileApps and SciDBs. Over the past decade I held many responsibilities including the direction of the development of scientific software applications for spectroscopy and general chemistry, directing marketing efforts, sales and business development collaborations for the company. Eight years experience of analytical laboratory leadership and management. Experienced in experimental techniques, implementation of new NMR technologies, walk-up facility management, research and development, manufacturing support and teaching. Ability to provide situation analysis, creative solutions and establish good working relationships. Prolific author with over a 150 peer-reviewed scientific publications, 3 patents and over 300 public presentations. Specialties Leadership in the domain of free access Chemistry, Product and project management, Organizational and Leadership development, Competitive analysis and Business Development, Entrepreneurial.
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Posted by on October 18, 2007 in ChemSpider Chemistry


0 Responses to A Challenge to the Synthetic Organic Chemist Community – Meet Quindolinocryptotackieine

  1. Antony Williams

    October 25, 2007 at 1:25 pm

    I’m happy to announce that a group has stepped up and shown interest in synthesizing the compound and are presently researching a synthetic path. If they choose to move forward then I will introduce them via this blog and we’ll track the work in the interests of Open Notebook Science


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