I’ve been writing a lot about the NPC Browser and NCGC data collection during the past few weeks. Today I was chatting about the software and content with a fellow advocate of online data for chemistry and I was asked for examples of “ridiculous content” that he might be able to refer to. He’d already read some of my earlier posts. It’s worth considering what the NPC Browser is supposed to deliver.
From the website the data collection is defined as:
“What is the NCGC Pharmaceutical Collection (NPC)?
The NCGC Pharmaceutical Collection (NPC) is a comprehensive, publically-accessible collection of approved and investigational drugs for high-throughput screening that provides a valuable resource for both validating new models of disease and better understanding the molecular basis of disease pathology and intervention. The NPC has already generated several useful probes for studying a diverse cross section of biology, including novel targets and pathways. NCGC provides access to its set of approved drugs and bioactives through the Therapeutics for Rare and Neglected Diseases (TRND) program and as part of the compound collection for the Tox21 initiative, a collaborative effort for toxicity screening among several government agencies including the US Environmental Protection Agency (EPA), the National Toxicology Program (NTP), the US Food and Drugs Administration (FDA), and the NCGC. Of the nearly 2750 small molecular entities (MEs) that have been approved for clinical use by US (FDA), EU (EMA), Japanese (NHI), and Canadian (HC) authorities and that are amenable to HTS screening, we currently possess 2400 as part of our screening collection.”
Some very interesting items have found there way into the database as mentioned previously. Sean Ekins also pointed out in a comment left out on a blog post that “American Cockroach” was also in the list. Really? Strangely enough….yes. See below.
There are many natural products that have become drugs…not so many insects though! Pop two under the tongue….likely to cause indigestion rather than cure it.
Other things included in the database are listed below…all as part of the NCGC pharmaceutical collection…bear bile??? Agh